Tsela e 'ngoe eo lisele tsa kankere li ipatang ka eona sesoleng sa' mele ke ka ho etsa mokoallo o mosesaane o bitsoang glycocalyx. Phuputsong e ncha, bafuputsi ba ile ba lekola thepa ea tšitiso ena ka tharollo e neng e e-so ka e bonoa, ba sibolla tlhahisoleseling e ka thusang ho ntlafatsa li-immunotherapies tsa morao-rao tsa mofets'e.
Hangata lisele tsa mofetše li etsa glycocalyx e nang le li-mucins tse ngata tsa sele, tseo ho nahanoang hore li thusa ho sireletsa lisele tsa mofetše tlhaselong ea lisele tsa 'mele. Leha ho le joalo, kutloisiso ea 'mele ea thibelo ena e ntse e lekanyelitsoe, haholo-holo mabapi le kankere ea cellular immunotherapy, e akarelletsang ho tlosa lisele tsa' mele tsa 'mele ho mokuli, ho li fetola ho batla le ho senya mofetše, ebe o li khutlisetsa ho mokuli.
"Re fumane hore liphetoho tsa botenya ba lithibelo tse nyane joalo ka li-nanometer tse 10 li ama ts'ebetso ea antitumor ea lisele tsa rona tsa 'mele kapa lisele tse entsoeng ke immunotherapy," ho boletse Sangwu Park, moithuti ea fumaneng mangolo laboratoring ea Matthew Paszek Univesithing ea Cornell e ISAB, New York. "Re sebelisitse tlhahisoleseling ena ho theha lisele tsa 'mele tsa ho itšireletsa mafung tse ka fetang glycocalyx,' me re tšepa hore mokhoa ona o ka sebelisoa ho ntlafatsa immunotherapy ea morao-rao." Biology.
"Lab ea rona e hlahisitse leano le matla le bitsoang scanning angle interference microscopy (SAIM) ho lekanya nanosized glycocalyx ea lisele tsa mofetše," ho boletse Park. "Mokhoa ona oa ho nka litšoantšo o re thusitse ho utloisisa kamano ea sebopeho sa li-mucins tse amanang le mofets'e le thepa ea biophysical ea glycocalyx."
Bafuputsi ba thehile mofuta oa cellular ho laola ka nepo polelo ea li-cell surface mucins ho etsisa glycocalyx ea lisele tsa mofetše. Eaba ba kopanya SAIM le mokhoa oa liphatsa tsa lefutso ho batlisisa hore na bokaholimo ba bokaholimo, glycosylation, le khokahano ea li-mucins tse amanang le mofets'e li ama botenya ba nanoscale barriers. Ba boetse ba hlahlobisisa kamoo botenya ba glycocalyx bo amang khanyetso ea lisele ho hlaseloa ke lisele tsa 'mele.
Boithuto bona bo bonts'a hore botenya ba sele ea mofets'e glycocalyx ke e 'ngoe ea lintlha tse ka sehloohong tse khethollang ho baleha ha lisele tsa' mele, le hore lisele tsa 'mele tsa boits'ireletso li sebetsa betere ha glycocalyx e le mosesaane.
Ho latela tsebo ena, bafuputsi ba thehile lisele tsa 'mele tsa ho itšireletsa mafung tse nang le li-enzyme tse khethehileng holim'a tsona tse li lumellang hore li hokahane le glycocalyx. Liteko tse maemong a lisele li bonts'itse hore lisele tsena tsa 'mele tsa ho itšireletsa mafung li khona ho hlola lihlomo tsa glycocalyx tsa lisele tsa mofetše.
Joale bafuputsi ba rera ho fumana hore na liphetho tsena li ka phetoa ka laboratoring ebe qetellong li lekoa litekong tsa bongaka.
Sangwoo Park e tla fana ka thuto ena (kakaretso) nakong ea "Regulatory Glycosylation in the Spotlight" ka Sontaha, March 26, 2-3 pm PT, Seattle Convention Center, room 608. Ikopanye le sehlopha sa mecha ea litaba bakeng sa boitsebiso bo eketsehileng kapa mahala mahala ho seboka.
Nancy D. Lamontagne ke sengoli sa saense le mohlophisi oa Creative Science Writing e Chapel Hill, North Carolina.
Kenya aterese ea hau ea lengolo-tsoibila 'me re tla u romella lingoliloeng tsa morao-rao, lipuisano le tse ling beke le beke.
Boithuto bo bocha ba Pennsylvania bo fana ka leseli la hore na liprotheine tse ikhethang li bula li-complexes tse thata tsa liphatsa tsa lefutso hore li sebelisoe.
May ke Kgwedi ya Temoso ya Mafu a Huntington, ka hona, a re ke re shebisiseng hore na ke eng le hore na re ka a alafa kae.
Bafuputsi ba Penn State ba fumane hore receptor ligand e tlama ntho e ngotsoeng 'me e khothalletsa bophelo bo botle ba mala.
Bafuputsi ba bonts'a hore li-phospholipid tse tsoang lijong tsa Bophirima li kenya letsoho ho eketseheng ha chefo ea baktheria ea mala, ho ruruha ha tsamaiso le ho thehoa ha letlapa la atherosclerotic.
Phetolelo e tlang pele "barcode". Ho tlosoa ha protheine e ncha mafung a boko. Limolek'hule tsa bohlokoa tsa lipid droplet catabolism. Bala lingoliloeng tsa morao-rao tse mabapi le lihlooho tsena.
Nako ea poso: May-22-2023